Fucoidan attenuates radioiodine-induced salivary gland dysfunction in mice
نویسندگان
چکیده
منابع مشابه
Resveratrol attenuates radiation-induced salivary gland dysfunction in mice.
OBJECTIVES/HYPOTHESIS In our study we investigated the radioprotective effect of resveratrol (RES) in a murine model of radiation-induced salivary gland dysfunction. STUDY DESIGN Ninety-six Institute of Cancer Research mice were randomly divided into four groups: solvent (group I), RES treated (group II; 20 mg/kg/d), 15 Gy irradiation with solvent treatment (group III), and 15 Gy irradiation ...
متن کاملSimvastatin attenuates radiation-induced salivary gland dysfunction in mice
OBJECTIVE Statins are widely used lipid-lowering drugs, which have pleiotropic effects, such as anti-inflammation, and vascular protection. In our study, we investigated the radioprotective potential of simvastatin (SIM) in a murine model of radiation-induced salivary gland dysfunction. DESIGN Ninety-six Institute of Cancer Research mice were randomly divided into four groups: solvent + sham ...
متن کاملPeroxynitrite formation in radiation-induced salivary gland dysfunction in mice.
Xerostomia frequently arises in patients with head and neck malignancies that are treated by radiation. However, the mechanisms responsible for the destruction of the salivary gland remain unknown. We previously established a xerostomia model of mice and identified the pathway through which nitric oxide (NO) affects the pathogenesis of radiation-induced salivary gland dysfunction. Although the ...
متن کاملSalivary and lacrimal gland dysfunction (sicca syndrome) after radioiodine therapy.
UNLABELLED Salivary gland dysfunction has been described in patients undergoing radioiodine therapy but associated lacrimal gland dysfunction (sicca syndrome) has never been reported. We conducted a prospective cohort study with follow-up for up to 3 y in a tertiary care university center to determine the prevalence of sicca syndrome in patients after high-dose radioiodine treatment. METHODS ...
متن کاملEffect of cevimeline on radiation-induced salivary gland dysfunction and AQP5 in submandibular gland in mice.
The aim of this study was to clarify the effects of the muscarinic receptor agonist, cevimeline, on saliva flow and expression of aquaporin5 (AQP5) in submandibular gland after X-ray irradiation. Using a previously established radiation-induced xerostomia model mouse, saliva flow from at 7 days before irradiation to at 28 days after irradiation was investigated in mice that were treated with ce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Oral Health
سال: 2019
ISSN: 1472-6831
DOI: 10.1186/s12903-019-0894-2